Principal Investigator
Takeshi Inagaki, M.D., Ph.D.
Takeshi Inagaki is a Professor in the Laboratory of Epigenetics and Metabolism at the Institute for Molecular and Cellular Regulation, Gunma University. He earned his M.D. and Ph.D. from Shinshu University, Nagano, Japan. From 2002 to 2008, he was a postdoctoral fellow and later an instructor in the laboratory of Drs. Steven Kliewer and David Mangelsdorf at the University of Texas Southwestern Medical Center, where he studied the roles of nuclear receptors and endocrine FGFs. From 2008 to 2016, he was an assistant professor and later an associate professor at the Research Center for Advanced Science and Technology at the University of Tokyo, where he studied metabolic regulations mediated by histone modifiers with Prof. Juro Sakai. Since 2016, he has been running a laboratory at Gunma University. He has consistently been interested in transcriptional regulation mechanisms and is investigating both the epigenetics and chromatin remodeling mechanisms that govern energy metabolism and the ways in which metabolites regulate the epigenome.
| Inagaki[at]gunma-u.ac.jp | |
| Tel | +81-27-220-8880 |
M.D.
Undergraduate / graduate combined program
Shinshu University School of Medicine, Nagano, Japan
Ph.D.
Aging Medicine and Geriatrics, Institute on Aging and Adaptation
Shinshu University Graduate School of Medicine, Nagano, Japan
・ Energy Metabolism
・ Epigenetics
・ Histone modifications and chromatin conformation
・ Nuclear receptors and endocrine FGFs
Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity
Suzuki T., Komatsu T., Shibata H., Tanioka A., Vargas D., Kawabata-Iwakawa R., Miura F., Masuda S., Hayashi M., Tanimura-Inagaki K., Morita S., Kohmaru J., Adachi K., Tobo M., Obinata H., Hirayama T., Kimura H., Sakai J., Nagasawa H., Itabashi H., Hatada I., Ito T., Inagaki T.* (2023).
Nucleic Acids Res. 51(12):6120-6142. PMID: 37158274
Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
Abe Y., Fujiwara Y., Takahashi h., Matsumura Y., Sawada T., Jiang S., Nakaki R., Uchida A., Nagao N., Naito M., Kajimura S., Kimura H., Osborne T.F., Aburatani H., Kodama T., Inagaki T.*, Sakai J.* (2018)
Nature Commun. 19;9(1):1566. PMID: 29674659
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis
Abe Y., Rozqie R., Matsumura Y., Kawamura T., Nakaki R., Tsurutani Y., Tanimura-Inagaki K., Shiono A., Magoori K., Nakamura K., Ogi S., Kajimura S., Kimura H., Tanaka T., Fukami K., Osborne T.F., Kodama T., Aburatani H., Inagaki T.*, Sakai J.* (2015)
Nature Commun. 7;6:7052. PMID: 25948511
The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis
Inagaki T.*, Iwasaki S., Matsumura Y., Kawamura T., Tanaka T., Abe Y., Yamasaki A., Tsurutani Y., Yoshida A., Chikaoka Y., Nakamura K., Magoori K., Nakaki R., Osborne T.F., Fukami K., Aburatani H., Kodama T., Sakai J.* (2015).
J. Biol. Chem. 290(7):4163-77. PMID: 25533466
Obesity and Metabolic Syndrome in Histone Demethylase JHDM2a Deficient Mice
Inagaki T., Tachibana M., Magoori K., Kudo H., Tanaka T., Okamura M., Naito M., Kodama T., Shinkai Y., Sakai J. (2009).
Genes to Cells 14(8):991-1001. PMID: 19624751
Inhibition of IGF-1 signaling and growth by the fasting-induced hormone FGF21
Inagaki T., Lin V.Y., Goetz R., Mohammadi M., Mangelsdorf D.J., Kliewer S.A. (2008).
Cell Metab. 8(1), 77-83. PMID: 18585098
Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21
Inagaki T., Dutchak P., Zhao G., Ding X., Gautron L., Parameswara V., Li Y., Goetz R., Mohammadi M., Esser V., Elmquist J.K., Gerard R.D., Burgess S.C., Hammer R.E., Mangelsdorf D.J., Kliewer S.A. (2007).
Cell Metab. 5(6), 415-425. PMID: 17550777
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J., Mangelsdorf D.J., Kliewer S.A. (2005).
Cell Metab. 2(4), 217-225. PMID: 16213224
・ Lilly Award, the Japan Diabetes Society (2018)
・ Japan Endocrine Society Research Award (2016)
・ Okamoto Research Award (2012)