業績集

  1. Transcriptional and epigenetic control of brown and beige adipocyte cell fate and function.
    Inagaki T., Sakai J, Kajimura S. (2016)
    Nature Reviews Molecular Cell Biology  17(8):480-95.  Review.  PMID: 27251423


  2. H3K4/H3K9me3 bivalent chromatin domains targeted by lineage-specific DNA methylation pauses adipocyte differentiation.  
    Matsumura Y., Nakaki R., Inagaki T., Yoshida A., Kano Y., Kimura H., Tanaka T., Tsutsumi S., Nakao M., Doi T., Fukami K., Osborne T.F., Kodama T., Aburatani H., Sakai J. (2015) 
    Molecular Cell  60, 584–596.  PMID: 26590716


  3. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
    Abe Y., Rozqie R., Matsumura Y., Kawamura T., Nakaki R., Tsurutani Y., Tanimura-Inagaki K., Shiono A., Magoori K., Nakamura K., Ogi S., Kajimura S., Kimura H., Tanaka T., Fukami K., Osborne T.F., Kodama T., Aburatani H., Inagaki T.*, Sakai J.* (2015)  
    Nature Communications 7;6:7052.  PMID: 25948511  (*Corresponding author)


  4. The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis. 
    Inagaki T.*, Iwasaki S., Matsumura Y., Kawamura T., Tanaka T., Abe Y., Yamasaki A., Tsurutani Y., Yoshida A., Chikaoka Y., Nakamura K., Magoori K., Nakaki R., Osborne T.F., Fukami K., Aburatani H., Kodama T., Sakai J.* (2015). 
    J. Biol. Chem. 
    290(7):4163-77.  PMID: 25533466  (*Corresponding author)


  5. Research perspectives on the regulation and physiological functions of FGF21 and its association with NAFLD.
    Inagaki T.* (2015)   
    Front. Endocrinol. (Lausanne)  6: 147.  Review.  PMID: 26441837  (*Corresponding author)


  6. Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver. 
    Raza-Iqbal S., Tanaka T., Anai M., Inagaki T., Matsumura Y., Ikeda K., Taguchi A., Gonzalez F.J., Sakai J., Kodama T. (2015) 
    J Atheroscler Thromb.
      22(8):754-72.  PMID: 26040752


  7. PPARβ/δ activation of CD300a controls intestinal immunity. 
    Tanaka T., Tahara-Hanaoka S., Nabekura T., Ikeda K., Jiang S., Tsutsumi S., Inagaki T., Magoori K., Higurashi T., Takahashi H., Tachibana K., Tsurutani Y., Raza S., Anai M., Minami T., Wada Y., Yokote K., Doi T., Hamakubo T., Auwerx J., Gonzalez F.J., Nakajima A., Aburatani H., Naito M., Shibuya A., Kodama T., Sakai J. (2014).   
    Scientific Reports   24;4:5412.  PMID: 24958459


  8. Dynamic change of the chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of HIF1 and KDM3A.
    Mimura I., Nangaku M., Kanki Y., Tsutsumi S., Inoue T., Kohro T., Yamamoto S., Fujita T., Shimamura T., Suehiro J.I., Taguchi A., Kobayashi M., Tanimura K., Inagaki T., Tanaka T., Hamakubo T., Sakai J., Aburatani H., Kodama T., Wada Y. (2012).   
    Mol. Cell. Biol. 32, 3018-3032.  PMID: 22645302


  9. Role of histone methylation and demethylation in adipogenesis and obesity.
    Okamura M., Inagaki T., Tanaka T., Sakai J. (2010).   
    Organogenesis 6(1):24-32.  Review.  PMID: 20592862


  10. Obesity and Metabolic Syndrome in Histone Demethylase JHDM2a Deficient Mice.
    Inagaki T., Tachibana M., Magoori K., Kudo H., Tanaka T., Okamura M., Naito M., Kodama T., Shinkai Y., Sakai J. (2009). 
    Genes to Cells  14(8):991-1001.  PMID: 19624751


  11. FGF21 induces PGC-1α and regulates carbohydrate and fatty acid. 
    Potthoff M.J., Inagaki T., Sapati S., Ding X, He T., Goetz R., Mohammadi M., Finck B.N, Mangelsdorf D.J., Kliewer S.A., Burgess S.C. (2009). 
    Proc. Natl. Acad. Sci. USA. 106(26), 10853-10858.  PMID: 19541642


  12. Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2. 
    Sakakibara I., Fujino T., Ishii M., Tanaka T., Shimosawa T., Miura S., Zhang W., Tokutake Y., Yamamoto J., Awano M, Iwasaki S., Motoike T., Okamura M., Inagaki T., Kita K., Ezaki O., Naito M., Kuwaki T., Chohnan S., Yamamoto T., Hammer R.E., Kodama T., Yanagisawa M., Sakai J. (2009).  
    Cell Metab.  9(1), 191-202.  PMID: 19187775


  13.  Inhibition of IGF-1 signaling and growth by the fasting-induced hormone FGF21.
    Inagaki T., Lin V.Y., Goetz R., Mohammadi M., Mangelsdorf D.J., Kliewer S.A.  (2008). 
    Cell Metab.  8(1), 77-83.  PMID: 18585098


  14. Partial resistance to peroxisome proliferator–activated receptor-α agonists in Zucker diabetic fatty (ZDF) rats is associated with defective hepatic mitochondrial metabolism.
    Satapati S., He T., Inagaki T., Potthoff M., Merritt ME., Esser V., Mangelsdorf D.J., Kliewer S.A., Browning J.D., Burgess S.C.  (2008).   
    Diabetes 57(8), 2012-21.  PMID: 18469201


  15. Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.
    Zhao G., Jeoung N.H., Burgess S.C., Rosaaen-Stowe K.A., Inagaki T., Latif S., Shelton J.M., McAnally J., Bassel-Duby R., Harris R.A., Richardson J.A., Kliewer S.A.  (2007).   
    Am. J. Physiol. Heart Circ. Physiol. 294(2), H936-43.  PMID: 18083902


  16. FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.
    Jung D., Inagaki T., Dawson P.A., Kliewer S.A., Mangelsdorf D.J., Moschetta A.  (2007).  
    J. Lipid Res. 48(12), 2693-700.  PMID: 17823457


  17. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine.
    Kim I., Ahn S-H, Inagaki T., Choi M., Ito S., Guo G.L., Kliewer S.A., Gonzalez F.J.  (2007).  
    J. Lipid Res. 48(12), 2664-72.  PMID: 17720959


  18. Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21. 
    Inagaki T., Dutchak P., Zhao G., Ding X., Gautron L., Parameswara V., Li Y., Goetz R., Mohammadi M., Esser V., Elmquist J.K., Gerard R.D., Burgess S.C., Hammer R.E., Mangelsdorf D.J., Kliewer S.A.  (2007).
    Cell Metab. 5(6), 415-425.  PMID: 17550777


  19. Molecular insights into the Klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
    Goetz R., Beenken A., Ibrahimi O.A., Kalinina J., Olsen S.K., Eliseenkova A.V., Xu C.F., Neubert T., Zhang F., Linhardt R.J., Yu X., White K.E., Inagaki T., Kliewer S.A., Yamamoto M., Kurosu H., Ogawa Y., Kuro-o M., Lanske B., Razzaque M.S., Mohammadi M.  (2007).
    Mol. Cell. Biol. 27(9), 3417-28.  PMID: 17339340


  20. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. 
    Inagaki T., Moschetta A., Lee Y-K, Peng L., Zhao G., Downes M., Yu R.T., Shelton J.M., Richardson J.A., Repa J.J., Mangelsdorf D.J., Kliewer S.A.  (2006).
    Proc. Natl. Acad. Sci. USA. 103(10), 3920-3925.  PMID: 16473946


  21. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
    Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J., Mangelsdorf D.J., Kliewer S.A.  (2005).  
    Cell Metab. 2(4), 217-225.  PMID: 16213224


  22.  A kindred with Cockayne syndrome caused by multiple splicing variants of the CSA gene.
    Komatsu A., Suzuki S., Inagaki T., Yamashita K., Hashizume K.  (2004).  
    Am. J. Med. Genet. 128A(1), 67-71.  PMID: 15211661


  23. Presence of functional domains in NADPH-dependent cytosolic 3,5,3′-Triiodo-L-thyronine (T3)-binding protein (p38CTBP) molecule: analyses with deletion mutants. 
    Suzuki S., Mori J.I., Kobayashi M., Inagaki T., Komatsu A., Yamashita K., Takeda T., Miyamoto T., Ichikawa K., Hashizume K.  (2003).  
    Horm. Metab. Res. 35(10), 577-82.  PMID: 14605990


  24. The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells. 
    Inagaki T., Suzuki S., Miyamoto T., Takeda T., Yamashita K., Komatsu A., Yamauchi K., Hashizume K.  (2003). 
    J. Biol. Chem. 278(51), 51685-92.  PMID: 14530287


  25. Cell-specific expression of NADPH-dependent cytosolic 3,5,3′-triiodo-L-thyronine-binding protein (p38CTBP). 
    Suzuki S., Mori J., Kobayashi M., Inagaki T., Inaba H., Komatsu A., Yamashita K., Takeda T., Miyamoto T., Ichikawa K., Hashizume K.  (2003).  
    Eur. J. Endocrinol. 148(2), 259-68  PMID: 12590647


  26. Fulminant diabetes mellitus associated with pregnancy: case reports and literature review. 
    Inagaki T.*, Nishii Y., Suzuki N., Suzuki S., Koizumi Y., Aizawa T., Hashizume K.  (2002).   
    Endocr. J. 49(3), 319-22.  PMID: 12201215  (*Corresponding author)


  27. Nicotinamide adenine dinucleotide phosphate-dependent cytosolic T(3) binding protein as a regulator for T(3)-mediated transactivation.
    Mori J., Suzuki S., Kobayashi M., Inagaki T., Komatsu A., Takeda T., Miyamoto T., Ichikawa K., Hashizume K.  (2002).    
    Endocrinology 143(4), 1538-44.  PMID: 11897713


  28. An ectopic ACTH-producing carcinoid tumor localized by the measurement of ACTH in the bronchial lavage.
    Kumagai M., Suzuki S., Yumita W., Minemura K., Ikeo Y., Inagaki T., Hiramatsu K., Aizawa T., Hashizume K.  (2001).    
    Endocr. J. 48(3), 363-7.  PMID: 11523908