Epigenome Research
The epigenome refers to the mechanisms that regulate gene expression without altering the underlying DNA sequence. As such, it represents a highly plastic system well-suited to responding to environmental changes. Our laboratory investigates how environmental factors are “memorized” within an individual’s biological constitution through epigenomic mechanisms—ultimately contributing either to the development of lifestyle-related diseases, such as obesity and diabetes mellitus, or to the maintenance of good health, with the aim of elucidating these processes at the molecular level.
We focus particularly on histone modifications, DNA methylation, and RNA methylation, exploring transcriptional regulatory mechanisms mediated by changes in chromatin structure and the formation of protein complexes, including nuclear receptors. Moving forward, our goal is to contribute to the development of novel therapeutic strategies for lifestyle-related diseases by gaining a precise and practical understanding of the molecular mechanisms that regulate cellular differentiation and energy metabolism.