PRINCIPAL INVESTIGATOR
Takeshi Inagaki, M.D, Ph.D.
Takeshi Inagaki is a Professor in the Laboratory of Epigenetics and Metabolism at the Institute for Molecular and Cellular Regulation, Gunma University. He received his M.D. and Ph.D. from Shinshu University. From 2002 to 2008, he was a postdoctoral fellow and instructor in the laboratory of Drs. Steven Kliewer and David Mangelsdorf at the University of Texas Southwestern Medical Center, where he studied the roles of nuclear receptors and endocrine FGFs. From 2008 to 2016, he served as an Assistant and subsequently Associate Professor at the Research Center for Advanced Science and Technology, the University of Tokyo, where he investigated metabolic regulation mediated by histone modifiers in the laboratory of Prof. Juro Sakai.
Since 2016, he has led the Laboratory of Epigenetics and Metabolism, where he investigates how cellular metabolic conditions are sensed and translated into cellular characteristics through the establishment of epigenetic memory. His research focuses on transcriptional regulatory mechanisms, particularly the epigenetic and chromatin remodeling processes that govern energy metabolism in response to metabolic cues.
・Mechanisms of metabolic regulation
・Epigenetics
・Transcriptional regulation via histone modifications and chromatin structure
・Nuclear receptors and endocrine FGFs
・Iron metabolism and epigenomic regulation
Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity.
Suzuki T., Komatsu T., Shibata H., Tanioka A., Vargas D., Kawabata-Iwakawa R., Miura F., Masuda S., Hayashi M., Tanimura-Inagaki K., Morita S., Kohmaru J., Adachi K., Tobo M., Obinata H., Hirayama T., Kimura H., Sakai J., Nagasawa H., Itabashi H., Hatada I., Ito T., Inagaki T.* (2023).
Nucleic Acids Res.51(12):6120-6142. PMID: 37158274 (*Corresponding author)
Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
Abe Y., Fujiwara Y., Takahashi h., Matsumura Y., Sawada T., Jiang S., Nakaki R., Uchida A., Nagao N., Naito M., Kajimura S., Kimura H., Osborne T.F., Aburatani H., Kodama T., Inagaki T.*, Sakai J.* (2018)
Nature Communications 19;9(1):1566. PMID: 29674659 (*Corresponding author)
Transcriptional and epigenetic control of brown and beige adipocyte cell fate and function.
Inagaki T., Sakai J, Kajimura S. (2016)
Nature Reviews Molecular Cell Biology 17(8):480-95. Review. PMID: 27251423
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Abe Y., Rozqie R., Matsumura Y., Kawamura T., Nakaki R., Tsurutani Y., Tanimura-Inagaki K., Shiono A., Magoori K., Nakamura K., Ogi S., Kajimura S., Kimura H., Tanaka T., Fukami K., Osborne T.F., Kodama T., Aburatani H., Inagaki T.*, Sakai J.* (2015)
Nature Communications 7;6:7052. PMID: 25948511 (*Corresponding author)
The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.
Inagaki T.*, Iwasaki S., Matsumura Y., Kawamura T., Tanaka T., Abe Y., Yamasaki A., Tsurutani Y., Yoshida A., Chikaoka Y., Nakamura K., Magoori K., Nakaki R., Osborne T.F., Fukami K., Aburatani H., Kodama T., Sakai J.* (2015).
J. Biol. Chem. 290(7):4163-77. PMID: 25533466 (*Corresponding author)
Obesity and Metabolic Syndrome in Histone Demethylase JHDM2a Deficient Mice.
Inagaki T., Tachibana M., Magoori K., Kudo H., Tanaka T., Okamura M., Naito M., Kodama T., Shinkai Y., Sakai J. (2009).
Genes to Cells 14(8):991-1001. PMID: 19624751
Inhibition of IGF-1 signaling and growth by the fasting-induced hormone FGF21.
Inagaki T., Lin V.Y., Goetz R., Mohammadi M., Mangelsdorf D.J., Kliewer S.A. (2008).
Cell Metab. 8(1), 77-83. PMID: 18585098
Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21.
Inagaki T., Dutchak P., Zhao G., Ding X., Gautron L., Parameswara V., Li Y., Goetz R., Mohammadi M., Esser V., Elmquist J.K., Gerard R.D., Burgess S.C., Hammer R.E., Mangelsdorf D.J., Kliewer S.A. (2007).
Cell Metab. 5(6), 415-425. PMID: 17550777
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
Inagaki T., Moschetta A., Lee Y-K, Peng L., Zhao G., Downes M., Yu R.T., Shelton J.M., Richardson J.A., Repa J.J., Mangelsdorf D.J., Kliewer S.A. (2006).
Proc. Natl. Acad. Sci. USA. 103(10), 3920-3925. PMID: 16473946
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J., Mangelsdorf D.J., Kliewer S.A. (2005).
Cell Metab. 2(4), 217-225. PMID: 16213224
The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells.
Inagaki T., Suzuki S., Miyamoto T., Takeda T., Yamashita K., Komatsu A., Yamauchi K., Hashizume K. (2003).
J. Biol. Chem. 278(51), 51685-92. PMID: 14530287
・Lilly Award, Japan Diabetes Society (2018)
・Research Encouragement Award, Japan Endocrine Society (2016)
・Okamoto Research Encouragement Award, Foundation for the Promotion of Adult Vascular Disease Research (2012)
E-mail: inagaki[at]gunma-u.ac.jp
Phone: +81-27-220-8880
Address:
Institute for Molecular and Cellular Regulation
Gunma University
3-39-15 Showa-machi, Maebashi,
Gunma 371-8512, Japan