Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity.
Suzuki T., Komatsu T., Shibata H., Tanioka A., Vargas D., Kawabata-Iwakawa R., Miura F., Masuda S., Hayashi M., Tanimura-Inagaki K., Morita S., Kohmaru J., Adachi K., Tobo M., Obinata H., Hirayama T., Kimura H., Sakai J., Nagasawa H., Itabashi H., Hatada I., Ito T., Inagaki T.* (2023).
Nucleic Acids Res. 51(12):6120-6142. PMID: 37158274
MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.
Takahashi H., Yang G., Yoneshiro T., Abe Y., Ito R., Yang C., Nakazono J., Okamoto-Katsuyama M., Uchida A., Arai M., Jin H., Choi H., Tumenjargal M., Xie S., Zhang J., Sagae H., Zhao Y., Yamaguchi R., Nomura Y., Shimizu Y., Yamada K., Yasuda S., Kimura H., Tanaka T., Wada Y., Kodama T., Aburatani H., Zhu M.-S., Inagaki T., Osborne T.F., Kawamura T., Ishihama Y., Matsumura Y., Sakai J. (2022).
Nat. Commun. 13(1):5715.
Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.
Katsumura S., Siddiqui N., Goldsmith M.R., Cheah J.H.; Fujikawa T., Minegishi G., Yamagata A., Yabuki Y., Kobayashi K., Shirouzu M., Inagaki T., Huang T. H.-M.; Mus N., Topisirovic I., Larsson O., Morita M. (2022).
Cell Metab. 34(4):564-580
Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis.
Matsumura Y., Ito R., Yajima A., Yamaguchi R., Tanaka T., Kawamura T., Magoori K., Abe Y., Uchida A., Yoneshiro T., Hirakawa H., Zhang J., Arai M., Yang C., Yang G., Takahashi H., Fujihashi H., Nakaki R., Yamamoto S., Satoshi Ota S., Tsutsumi S., Inoue S.I., Kimura H., Wada Y., Kodama T., Inagaki T., Osborne T., Aburatani H., Node K., Sakai J. (2021).
Nat. Commun. 12(1):7045.
T1R3 homomeric sweet taste receptor negatively regulates insulin-induced glucose 2 transport through Gαs-mediated microtubules disassembly in 3T3-L1 adipocytes.
Masubuchi Y., Ma J., Suzuki T., Kojima I., Inagaki T., Shibata H. (2021).
Endocr. J. https://doi.org/10.1507/endocrj.EJ21-0661
Bacteroides promotes branched-chain amino acid catabolism in brown fat and inhibits obesity.
Yoshida N., Yamashita T., Osone T., Hosooka T., Shinohara M.,Kitahama S., Sasaki K., Sasaki D.,Yoneshiro T., Suzuki T., Emoto T., Saito Y., Ozawa G., Hirota Y., Kitaura Y., Shimomura Y., Okamatsu-Ogura Y., Saito M., Kondo A., Kajimura S., Inagaki T., Ogawa W., Yamada T., Hirata K.I. (2021).
iScience 24(11):103342
Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals.
Suzuki T., Hayashi M., Komatsu T., Tanioka A., Nagasawa M., Tanimura-Inagaki K., Rahman M.S., Masuda S., Yusa K., Sakai J., Shibata H., Inagaki T. (2021).
Endocr. J. 68(12):1429-1438.
Ubiquitination-dependent and -independent repression of target genes by SETDB1 reveal a context-dependent role for its methyltransferase activity during adipogenesis.
Zhang J., Matsumura M., Kano Y., Yoshida A., Kawamura T., Hirakawa H., Inagaki T., Tanaka T., Kimura H., Yanagi S., Fukami K., Doi T., Osborne T.F., Kodama T., Aburatani H., Sakai J. (2021).
Genes Cells 26(7):513-529
PPARα activation directly upregulates thrombomodulin in the diabetic retina.
Shiono A., Sasaki H., Sekine R., Abe Y., Matsumura Y., Inagaki T., Tanaka T., Kodama T., Aburatani H., Sakai J., Takagi H. (2020).
Sci. Rep. 10(1):10837
Epigenetic regulation of beige adipocyte fate by histone methylation.
Tanimura K., Suzuki T., Vargas D., Shibata H., Inagaki T. * (2018).
Endocr. J. 66(2):115-125
Histone demethylases regulate adipocyte thermogenesis.
Inagaki T.* (2018).
Diabetol. Int. 9(4): 215-223
Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.
Abe Y., Fujiwara Y., Takahashi h., Matsumura Y., Sawada T., Jiang S., Nakaki R., Uchida A., Nagao N., Naito M., Kajimura S., Kimura H., Osborne T.F., Aburatani H., Kodama T., Inagaki T.*, Sakai J.* (2018).
Nat. Commun. 19;9(1):1566. PMID: 29674659
Regulations of Adipocyte Phenotype and Obesity by IRX3. Positive or Negative?
Inagaki T.* (2017).
eBioMedicine 24:7–8. PMID: 28967609
Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression.
Fukunaka A., Fukada T, Bhin J.H., Suzuki L., Tsuzuki T., Takamine Y., Bin B.H., Yoshihara T.,Ichinoseki-Sekine N., Naito H., Miyatsuka T., Takamiya S., Sasaki T., Inagaki T., Kitamura T., Kajimura S., Watada H., Fujitani Y. (2017).
PLoS Genet. 13(8):e1006950. PMID: 28854265
T1R3 Homomeric Sweet Taste Receptor Regulates Adipogenesis Through Gαs-Mediated Microtubules Disassembly and Rho Activation in 3T3-L1 Cells.
Masubuchi Y., Nakagawa Y., Medina J., Nagasawa M., Kojima I., Rasenick MM., Inagaki T., Shibata H. (2017).
PLoS One. 4;12(5):e0176841. PMID: 28472098
Transcriptional and epigenetic control of brown and beige adipocyte cell fate and function.
Inagaki T., Sakai J., Kajimura S. (2016).
Nat. Rev. Mol. Cell Biol. 17(8):480-95. Review. PMID: 27251423
H3K4/H3K9me3 bivalent chromatin domains targeted by lineage-specific DNA methylation pauses adipocyte differentiation.
Matsumura Y., Nakaki R., Inagaki T., Yoshida A., Kano Y., Kimura H., Tanaka T., Tsutsumi S., Nakao M., Doi T., Fukami K., Osborne T.F., Kodama T., Aburatani H., Sakai J. (2015).
Mol. Cell 60, 584–596. PMID: 26590716
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Abe Y., Rozqie R., Matsumura Y., Kawamura T., Nakaki R., Tsurutani Y., Tanimura-Inagaki K., Shiono A., Magoori K., Nakamura K., Ogi S., Kajimura S., Kimura H., Tanaka T., Fukami K., Osborne T.F., Kodama T., Aburatani H., Inagaki T.*, Sakai J.* (2015).
Nature Commun. 7;6:7052. PMID: 25948511
The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.
Inagaki T.*, Iwasaki S., Matsumura Y., Kawamura T., Tanaka T., Abe Y., Yamasaki A., Tsurutani Y., Yoshida A., Chikaoka Y., Nakamura K., Magoori K., Nakaki R., Osborne T.F., Fukami K., Aburatani H., Kodama T., Sakai J.* (2015).
J. Biol. Chem. 290(7):4163-77. PMID: 25533466
Research perspectives on the regulation and physiological functions of FGF21 and its association with NAFLD.
Inagaki T.* (2015).
Front. Endocrinol. (Lausanne) 6: 147. Review. PMID: 26441837
Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.
Raza-Iqbal S., Tanaka T., Anai M., Inagaki T., Matsumura Y., Ikeda K., Taguchi A., Gonzalez F.J., Sakai J., Kodama T. (2015).
J. Atheroscler. Thromb. 22(8):754-72. PMID: 26040752
PPARβ/δ activation of CD300a controls intestinal immunity.
Tanaka T., Tahara-Hanaoka S., Nabekura T., Ikeda K., Jiang S., Tsutsumi S., Inagaki T., Magoori K., Higurashi T., Takahashi H., Tachibana K., Tsurutani Y., Raza S., Anai M., Minami T., Wada Y., Yokote K., Doi T., Hamakubo T., Auwerx J., Gonzalez F.J., Nakajima A., Aburatani H., Naito M., Shibuya A., Kodama T., Sakai J. (2014).
Sci. Rep. 24;4:5412. PMID: 24958459
Dynamic change of the chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of HIF1 and KDM3A.
Mimura I., Nangaku M., Kanki Y., Tsutsumi S., Inoue T., Kohro T., Yamamoto S., Fujita T., Shimamura T., Suehiro J.I., Taguchi A., Kobayashi M., Tanimura K., Inagaki T., Tanaka T., Hamakubo T., Sakai J., Aburatani H., Kodama T., Wada Y. (2012).
Mol. Cell. Biol. 32, 3018-3032. PMID: 22645302
Role of histone methylation and demethylation in adipogenesis and obesity.
Okamura M., Inagaki T., Tanaka T., Sakai J. (2010).
Organogenesis 6(1):24-32. Review. PMID: 20592862
Obesity and Metabolic Syndrome in Histone Demethylase JHDM2a Deficient Mice.
Inagaki T., Tachibana M., Magoori K., Kudo H., Tanaka T., Okamura M., Naito M., Kodama T., Shinkai Y., Sakai J. (2009).
Genes Cells 14(8):991-1001. PMID: 19624751
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid.
Potthoff M.J., Inagaki T., Sapati S., Ding X, He T., Goetz R., Mohammadi M., Finck B.N, Mangelsdorf D.J., Kliewer S.A., Burgess S.C. (2009).
Proc. Natl. Acad. Sci. USA. 106(26), 10853-10858. PMID: 19541642
Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2.
Sakakibara I., Fujino T., Ishii M., Tanaka T., Shimosawa T., Miura S., Zhang W., Tokutake Y., Yamamoto J., Awano M, Iwasaki S., Motoike T., Okamura M., Inagaki T., Kita K., Ezaki O., Naito M., Kuwaki T., Chohnan S., Yamamoto T., Hammer R.E., Kodama T., Yanagisawa M., Sakai J. (2009).
Cell Metab. 9(1), 191-202. PMID: 19187775
Inhibition of IGF-1 signaling and growth by the fasting-induced hormone FGF21.
Inagaki T., Lin V.Y., Goetz R., Mohammadi M., Mangelsdorf D.J., Kliewer S.A. (2008).
Cell Metab. 8(1), 77-83. PMID: 18585098
Partial resistance to peroxisome proliferator–activated receptor-α agonists in Zucker diabetic fatty (ZDF) rats is associated with defective hepatic mitochondrial metabolism.
Satapati S., He T., Inagaki T., Potthoff M., Merritt ME., Esser V., Mangelsdorf D.J., Kliewer S.A., Browning J.D., Burgess S.C. (2008).
Diabetes 57(8), 2012-21. PMID: 18469201
Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.
Zhao G., Jeoung N.H., Burgess S.C., Rosaaen-Stowe K.A., Inagaki T., Latif S., Shelton J.M., McAnally J., Bassel-Duby R., Harris R.A., Richardson J.A., Kliewer S.A. (2007).
Am. J. Physiol. Heart Circ. Physiol. 294(2), H936-43. PMID: 18083902
FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.
Jung D., Inagaki T., Dawson P.A., Kliewer S.A., Mangelsdorf D.J., Moschetta A. (2007).
J. Lipid Res. 48(12), 2693-700. PMID: 17823457
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine.
Kim I., Ahn S-H, Inagaki T., Choi M., Ito S., Guo G.L., Kliewer S.A., Gonzalez F.J. (2007).
J. Lipid Res. 48(12), 2664-72. PMID: 17720959
Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21.
Inagaki T., Dutchak P., Zhao G., Ding X., Gautron L., Parameswara V., Li Y., Goetz R., Mohammadi M., Esser V., Elmquist J.K., Gerard R.D., Burgess S.C., Hammer R.E., Mangelsdorf D.J., Kliewer S.A. (2007).
Cell Metab. 5(6), 415-425. PMID: 17550777
Molecular insights into the Klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Goetz R., Beenken A., Ibrahimi O.A., Kalinina J., Olsen S.K., Eliseenkova A.V., Xu C.F., Neubert T., Zhang F., Linhardt R.J., Yu X., White K.E., Inagaki T., Kliewer S.A., Yamamoto M., Kurosu H., Ogawa Y., Kuro-o M., Lanske B., Razzaque M.S., Mohammadi M. (2007).
Mol. Cell. Biol. 27(9), 3417-28. PMID: 17339340
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
Inagaki T., Moschetta A., Lee Y-K, Peng L., Zhao G., Downes M., Yu R.T., Shelton J.M., Richardson J.A., Repa J.J., Mangelsdorf D.J., Kliewer S.A. (2006).
Proc. Natl. Acad. Sci. USA. 103(10), 3920-3925. PMID: 16473946
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J., Mangelsdorf D.J., Kliewer S.A. (2005).
Cell Metab. 2(4), 217-225. PMID: 16213224
A kindred with Cockayne syndrome caused by multiple splicing variants of the CSA gene.
Komatsu A., Suzuki S., Inagaki T., Yamashita K., Hashizume K. (2004).
Am. J. Med. Genet. 128A(1), 67-71. PMID: 15211661
Presence of functional domains in NADPH-dependent cytosolic 3,5,3′-Triiodo-L-thyronine (T3)-binding protein (p38CTBP) molecule: analyses with deletion mutants.
Suzuki S., Mori J.I., Kobayashi M., Inagaki T., Komatsu A., Yamashita K., Takeda T., Miyamoto T., Ichikawa K., Hashizume K. (2003).
Horm. Metab. Res. 35(10), 577-82. PMID: 14605990
The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells.
Inagaki T., Suzuki S., Miyamoto T., Takeda T., Yamashita K., Komatsu A., Yamauchi K., Hashizume K. (2003).
J. Biol. Chem. 278(51), 51685-92. PMID: 14530287
Cell-specific expression of NADPH-dependent cytosolic 3,5,3′-triiodo-L-thyronine-binding protein (p38CTBP).
Suzuki S., Mori J., Kobayashi M., Inagaki T., Inaba H., Komatsu A., Yamashita K., Takeda T., Miyamoto T., Ichikawa K., Hashizume K. (2003).
Eur. J. Endocrinol. 148(2), 259-68 PMID: 12590647
Fulminant diabetes mellitus associated with pregnancy: case reports and literature review.
Inagaki T.*, Nishii Y., Suzuki N., Suzuki S., Koizumi Y., Aizawa T., Hashizume K. (2002).
Endocr. J. 49(3), 319-22. PMID: 12201215
Nicotinamide adenine dinucleotide phosphate-dependent cytosolic T(3) binding protein as a regulator for T(3)-mediated transactivation.
Mori J., Suzuki S., Kobayashi M., Inagaki T., Komatsu A., Takeda T., Miyamoto T., Ichikawa K., Hashizume K. (2002).
Endocrinology 143(4), 1538-44. PMID: 11897713
An ectopic ACTH-producing carcinoid tumor localized by the measurement of ACTH in the bronchial lavage.
Kumagai M., Suzuki S., Yumita W., Minemura K., Ikeo Y., Inagaki T., Hiramatsu K., Aizawa T., Hashizume K. (2001).
Endocr. J. 48(3), 363-7. PMID: 11523908