Epigenetic regulation of gene expression is independent of genomic sequence and therefore can flexibly respond to environmental factors. We are currently investigating various epigenetic mechanisms by which the environmental factors are linked to metabolic diseases. Main focus of our research is histone modification which regulates gene expression through changing chromatin structure and cofactor recruitment. Using techniques of transcriptomics, epigenetics, proteomics and animal models, we intend to elucidate the detail mechanisms of epigenetic regulations of energy metabolism and adipose cell development.